Recently I saw a cartoon in Tapestry that took a little while to sink in. The cartoon was a take-off on the drug addiction awareness ads running in many national publications. The original ad went something like this, “This is Crack, this is your brain on crack”. This cartoon substituted “Premarin” for “Crack” and showed the brain image as flowers, rainbows, etc.. At first I thought it amusing and a novel parody but the more I thought about it, the more serious it became.

The mind and what it perceives govern our lives. We as members of the “gender community” have decided to explore our minds and likewise our inner desires. In many cases, we are now able to express that inner self publicly. We have allowed our “inner self” to come out into the light of day, to be expressed openly and we are, “on a grow”, as a good friend of mine puts it.

However, we need to be clear headed and rational in our exploration of this inner self. We need to be able to evaluate ourself clearly and choose the right path at each and every fork in the road, less we wake up some day realizing that where we are now is not the place that we started out heading toward. Worse yet we may have no way to go back.

Everyone knows the physical effects which hormones produce. However, a powerful influence which may not be apparent to some is the effect of hormones on our mind. Most people do not realize that these chemicals have a dramatic effect on our mind as well as our bodies. If you want proof, just ask any “natural” woman how her mood, attitudes, and ability to function varies at times due to her natural cycle. In the case of a person on large doses of hormones being used to cause a gender change combined with the natural hormones present of the person’s original gender and one may end up with a mental state the equivalent of a bottle of nitroglycerin ready to blow at the slightest jarring.

For those who choose to experiment with hormones in a non-controlled environment, the situation is extremely dangerous. Supervision is the key here. Not just physical supervision which is usually provided by a family doctor or an endocrinologist but psychological supervision by a professional trained in “gender therapy”. A professional who is keenly aware of the mind altering properties of these drugs and a professional trained to observe subtle attitude shifts. One needs this kind of care to prevent the worst from happening. It would be horrible to wake up one day and realize that during a long sleep we now have mutilated our body, have lost the support of our family, are broke, without a job and on the verge of suicide.

Don’t get me wrong, I’m not negative on hormones. I feel that they can perform nothing short of a miracle to modify one’s physical and mental being thereby correcting what I feel is a major birth effect, but the key is to use these chemicals in a controlled environment.

A good friend of mine related to me how he (she) was on a rocket ship for about six months. At the beginning of the period she began a program of hormone treatment wanting to become more feminine to “see how it felt”. After about four months on a fairly high dosage program (5-mg/day), she was seriously contemplating a trip to Colorado for reassignment surgery. Within a month after she stopped treatment, she was still positive about being able to express her internal “second self” but surgery was no longer an immediate goal. She may someday have surgery but has decided that for now, the immediate gains would not be worth the price which must be paid, i.e. the loss of her family and career.

For others hormones and the effect on their minds had meant the opposite. The effect seems to have been to allow these people to more clearly see how comfortable they are in their new chosen gender. After hormone treatment their path became clear and the internal conflict which had been a life-long strife was resolved.

Hormone therapy can both resolve and create problems and should be administered with this in mind. In most cases, I would advise that the person discontinue use for a period after the initial effects have begun to take hold. This break will allow for the “hormone high” to subside and give the person a time to reevaluate where they want to go. A period of a month or so won’t hurt any long term progress that is desired and it will give the person’s mind a chance to return to their pre-hormone thought patterns. Therapy during this period is very important, and an in depth consultation should precede the continuance of hormone therapy. Questions such as “what am I gaining and what am I giving up? should be asked. If the answers are not conclusive, then continuance of hormone therapy should be postponed until some point of resolution of there questions is possible. If hormone therapy is reinstituted at this time, it may conceal the true inner self and the replies may only be those reflecting the person’s “hormone high”.

Successful “gender therapy” is the desired result and proper application of the methods and therapy (including hormone therapy) are the tools.  These tools should be used under the close supervision of a trained gender therapist. If the methodology described here is followed, I feel that the person has a better chance of attaining a true peace and contentment with the true inner self.

* (C) Copyright 1990 by  Wendi D. Pierce.   All rights reserved.  Permission to reprint this article in publications of the gender community is hereby  granted provided that this article is published in it’s entirety including this notice and  credit is given to the author.


  1. denise

    The pleasure of dressing the feeling this sissy gets s(he) didn’t get that pleasure from taking hormones this sissy will make h(er) own hormones thank you be who s(he) is to the end
    High heals nylons lace trimmed panties lace trimmed full slip tear drop earrings hair extensions makeup eyeshadow eyeliner on bended knees ready to serve a Superior this sissy hopes s(he) hasn’t offended any of sisters

  2. donnie

    This material brings back wistful memories. After years of hesitation and struggles with low self-esteem, and after years of seeking help from therapists,
    this sissy started a regimen of self-injected estradiol valerate and oral spironolactone under doctoral supervision. S.he continued to meet regularly with a gender therapist as this regime played out for 2 years and nine months.
    Over time, subtly at first, then with growing intensity, he.r nipples became sensitive and even sore (to lie face down for example). He.r increasing breast tissue became impossible to hide at the end and s.he remembers becoming very protective of he.r new swelling mounds, wearing bulky sweatshirts or even just covering up with a towel or both hands. He.r usual habit was to fold he.r arms over her breasts to hide them. Just putting on a certain fabric shirt or blouse would set he.r sensitive nipples off. There seemed to be a much more direct, hard wired, connection between he.r larger nipples and her spine and groin….everything would become aroused at once.
    This sissy’s hair has always been long, but during those years s.he was thrilled to often be referred to as a woman when in stores or out on the street when not even dressed. It was almost as if there was a glow or assumed aura (maybe a smell?) that people seemed to pick up on.
    When this sissy did indulge with masturbation, orgasms became less frequent, but, when experienced, they became much more prolonged and intense
    involving more of he.r whole body and spine….truly exhausting in a good way.
    This sissy loved these changes and wishes s.he had had the opportunity, the financial means, the support network, and a true, loving mentor to continue these changes. And yes, he.r sissy clit did shrink as time went on, but s.he loved it!

  3. antje

    ich möchte auch gern noch weiblicher werden und möchte Hormone nehmen. Meine Frau weiss Bescheid und unterstützt mich ganz toll. Sie möchte das ich eine hübsche Frau werde, da sie etwas bisexuell ist. Endlich kann ich so werden wie ich innelich bin.

  4. amra stone

    wow i only started to deal with the women i am 4 yrs ago, im 52. in therapy, and want to take hormones for few months as mentioned above then stop see how i feel. part of ut is beca i dont want co workers b to see drastic changes yet will truely allow me to see how i feel. then make plans to move to transition. its so wow overwhelming at times. i hope we all get thru this time in our lifes. yet a struggle i feel its made me more compassionate towords others who struggles. peace amra

  5. Natalie

    Wow, with each turn of a page on this site I become more impressed with the information here. Several of the postings here spoke to me and echoed my own processes. I’ve been on my own journey since childhood, at early infancy suffered an extreme emotional loss. At early adolescence had an intense curiosity in “women’s issues”. Throughout various times and stages of adulthood alternate gender choices presented themselves, only to have me continue to sublimate them; leaving me each time to determine I’d made a permanent choice to be male. And, still the choices continued to re-present themselves, even if infrequently.
    Recently, I’ve been working with someone who has an innate sense of who I am inside and has shown compassion, understanding and much patience. I’m grateful to her, she really is a manifestation of the Divine Goddess. What seems to make sense is for me to locate a suitable “gender therapist” as I have a number of issues and want assistance to work them through. I’m also appreciative of the humans who put this site together and maintain it. I’ve been learning much in my short time here and it’s giving me much to consider. Keep up the good work.
    The Emerging Natalie and (her male counterpart) Michael

  6. veronica

    Firstly, thank you for a wonderful well thought out article. I have been “dealing” with gender confusion for the majority of my life. (I’m about to turn 54). and by “dealing” I mean denying my feelings for a long time. It is only within the last 5 years or so that I have begun to accept this part of me that is really so central to who I am. It is only recently, when my wife found out about these feelings that I’ve been able to look at them in an open way. I’m working with a gender specialist and one thing that I’ve come to realize is that the form I have (and was born with) is not the form I want (or think that I need). Will I start HRT? I may, but I’m at the very beginning of understanding who I really am and before I even go the HRT route, I need to spend the time working on me. In my more honest moments, I see that I’ve enjoyed a very priveleged existence and loss of privelege scares me. The suggestion to pause HRT in order to reflect on changed and determine if your really headed in the direction you wish makes so much sense to me. Thank you once again for giving us food for thought.

    1. Madame Stewart

      It’s a very serious thing to start HRT, and is often irreversible. The girl who loves her sexuality will find it affected by the estrogen – and it makes it difficult to go back and forth. The “Bullet Train to Trinidad” is a very real deal – and this article is for that thought. Glad you liked it!

  7. Danielle

    I want to be more feminine in my looks and most certainly my mind although I don’t want to loose certain parts of me and the necessary functionality!

    Would love my own natural breasts and am considering the herbal route to acheive this, any advice would be most welcome.

  8. jamie

    I don’t want to become a female completely, but I DO want to loose a lot of my male characteristics (emotional) and adopt more female characteristics (understanding and compassion). I don’t mind if my body takes on a “softer, less male” appearance. I have begun taking over-the-counter herbal hormone-replacement supplements from the local herbal nutrition shop. Am I making a big mistake?

  9. miranda

    I have taken female hormones with only slight changes I am married mrs knows that I like to dress up but we haven’t discussed it yet. I only do it when I am on my own. At work I get some looks it hasn’t been discussed their either but the boss knows and pretty much everyone else. My mum and dad I see them quite often and they know but we don’t discuss it. Everything seems so complicated!!

  10. connie

    been a while since i visited this page, but stirs deep feelings. took your advice and now see my wife’s doctor. all is well and i am much happier. my old doctor is still there, and sees me if my doctor is absent.

  11. stacirenee6569

    being transexual is not an easy task for anyone to partake in journey. generally a lifelong education or processes. i too agree as far as hormone regimens to be done by licensed doctor, as well as have therapist involved. it’s nothing to take lightly. being initially embarressed, is far better than death. i’m a b-cup, third time round. fear of telling your doctor. conquer your fears or suck it up n do nothing. far better to move forward in your life, as well as mind. as far as hormones, i to agree with mstewart.

  12. connie

    gracious curtsies, i have been taking low dosage estrogen some time now and recently started some breast enhancement supplements, my doctor is telling me i am healthy but questioning my goals. How do i deal with a medical professional that is aware of my tampering with nature, but objects. He has suggested that i switch from him to my wife’s doctor, who shares his practice?

  13. lindav

    dear Ma’am have recently started taking breast supplements is this the same as hormones and what effects are likely to take place. sissy has an appointment with her therapist in the morning. sissy really cant tell on her own if any thing is happening or just her mind playing tricks with her. any thoughts would be greatly appreciated with great respect and admiration sissy linda marie

  14. pinkbeeme

    Ms. Wendi,

    What a very insightful piece. Sometimes i am not sure if i am just a man that likes to wear panties, a closet homo, or a female trapped inside a male body.

    My upbringing turn me into macho man, but my compassion and love for the tenderness associated with being female draws the feminine side of me to the surface.

    Where as it was at first just to be dominated it’s developing into something much more as i learn more about myself and the lifestyle many are opting for as they discover the same things hold true for them.

    Thank You for another piece of the puzzle that your article brings to light.

  15. lilith

    i would love to get on a real hormonal regimen. But as it is i found the back door to the process. Emerita progesterone and phytoestrogen cremes. Plus the ingestion of vitamin supplements like black cohosh. The results are far less dramatic, but still satisfying. i will be satisfied when i get to a solid “B” bra size. It’s much easier to find bras that fit.
    The “psych” part? mommy dearest dressed me as a girl from the day i got out of the hospital to about 4-5 years old. i fought reality for decades trying to live up to my “penis” status and was absolutely miserable. i’m just trying to get my body to reflect, to some small degree, what i feel i am. A girl.

Something to share sweetie?